Where is ibuprofen broken down

For example, acetaminophen is broken down and removed by the liver. Acetaminophen has a warning about liver damage it can cause that can be fatal cause death. Liver damage can happen if you take too much in a hour period. For more information, read about the dangers of acetaminophen overdose. Ibuprofen, on the other hand, is removed from your body by your kidneys. Taking it for a long time can cause kidney damage and stomach bleeding.

Using high doses of ibuprofen for longer than recommended can increase your risk of:. Acetaminophen and ibuprofen can cause dangerous interactions when you take them with certain medications. To reduce your risk, make sure you tell your doctor about all drugs, supplements, and herbs you take.

Taking either acetaminophen or ibuprofen may cause problems if you have certain health issues. Talk to your doctor before using acetaminophen or ibuprofen if you have:.

Acetaminophen and ibuprofen both treat pain, but they work slightly differently in your body. Each drug can pose different safety issues, especially if you have existing health conditions. How different can they be? Learn more to judge for yourself. Over-the-counter anti-inflammatory drugs help reduce pain. Learn how they work. Also discover which ones are safe for children, warnings, and other….

But is Tylenol anti-inflammatory? Learn the answer to this question and important differences between these…. In the U. People tend to use it to relieve pain or the symptoms of a mild cold. Like any other drug, ibuprofen can have side effects.

One of them is liver damage , though this is rare. As a result, medication can have unintended effects on the liver. To determine the true capacity of ibuprofen to cause liver problems, the researchers regularly administered moderate amounts of ibuprofen to mice for 1 week. The drug dosage was the equivalent of an adult human taking around milligrams of ibuprofen per day.

At the end of the week, the investigators used advanced mass spectrometry — a set of techniques that allow scientists to establish the ratio and type of chemicals present in a laboratory sample at any given time. Aldrin Gomes. The changes were different, depending on the sex of the mice. Meanwhile, in female — but not in male — mice, the ibuprofen regimen increased the activity of some cytochrome Ps, a class of enzyme that contributes to the breakdown of drugs.

Gomes emphasizes. Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Request an Appointment at Mayo Clinic.

Normal liver vs. Share on: Facebook Twitter. Show references Andrade RJ, et al. Journal of Hepatology. In press. April 24, Burt AD, et al, eds. Drugs and toxins. In: MacSween's Pathology of the Liver.

Philadelphia, Pa. Accessed April 24, Liver injury caused by drugs. Merck Manual Professional Version. Accessed May 4, Larson AM. Drug-induced liver injury. Yeo CJ. Laboratory measurement of hepatic function. In: Shackelford's Surgery of the Alimentary Tract. Acetaminophen poisoning. Nader R. Liver disease. Picco MF expert opinion. Mayo Clinic, Jacksonville, Fla.